#17 USC vs #8 Oregon NCAAF Pick: High Stakes Big Ten Battle (Nov 22)

Published Nov 18, 10:26am ET by

Gabriel Kozlow - Betting Preview Analyst and Sports Writer

Last updated Nov 18, 10:26am ET

Pick status
Oklahoma State will play BYU in the NCAAF on October 18

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Updated Nov 18, 10:26am ET

  • #17 USC (8-2) are coming off a tough 26-21 win versus Iowa.
  • #8 Oregon (9-1) beat Minnesota comfortably with a 42-13 victory.
  • Their last matchup was on November 11th, 2023, where Oregon defeated USC 36-27.

The USC Trojans pay a visit to Eugene this weekend in a high-stakes matchup against the Oregon Ducks. The last time USC traveled to Oregon, it didn’t end well for the Trojans. However, they still lead the all-time series with a 38-23-2 record.

OREGON DUCKS vs. USC TROJANS Overview Watch On: CBS

DATE & TIME

SATURDAY, NOVEMBER 22ND, 2025 @ 2:30 PM ET
OREGON DUCKS
Autzen Stadium
Eugene, OR
USC TROJANS
GAME ODDS
BetOnline
OREGON DUCKS -400
USC TROJANS +300

Trojans Battle for West-Coast Supremacy

USC arrives in Eugene ranked #17 in the nation and fully aware of the stakes in this game. The Trojans know this is a make-or-break moment in their season. They enter as underdogs but come in looking to prove a point. USC will need discipline on both offense and defense, along with a bit of luck when it matters most.

USC’s QB, Jayden Maiava, has thrown 18 touchdowns this season along with 6 interceptions. Most importantly, in last week’s game versus Iowa, he finally broke his five-game streak of throwing an interception — something he’ll need to maintain against the Ducks. He’ll be looking to connect with his star wide receiver, Makai Lemon, who has already recorded 8 touchdowns and 71 receptions this year.

Ducks Fly High in Front of Home Crowd

The Oregon Ducks are ranked #8 in the country and have had a fantastic season so far. However, they’ll need to prove once again why they deserve to be considered among the nation’s best with a win over USC this weekend. With momentum on their side and the home crowd behind them, they enter the game as favorites at -10.5.

The Ducks are known for their fierce defense, allowing just 13.7 points per game this season. Those numbers will be interesting to watch as they face a USC team averaging 38.2 points per game. The most points Oregon has allowed this season is 24, coming in a double-overtime thriller against Penn State.

#17 USC vs #8 Oregon NCAAF Pick

This is a massive game for both teams and will undoubtedly be a nail-biter, as each side needs a win. The home-team Ducks are favored at -10.5, with an over/under set at 59.5. The moneyline sits at -400 for Oregon and +300 for USC.

The Ducks have proven to be strong on both offense and defense this season, and with their home crowd on their side, they should have no problems handling the Trojans. Our pick for this game is Oregon -10.5 on the spread.

Pick
Oregon -10.5
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