#10 LSU vs #17 Vanderbilt NCAAF Pick: SEC Showdown in Week 8 (Oct 18)

Published Oct 16, 12:26am ET by

Gabriel Kozlow - Betting Preview Analyst and Sports Writer

Last updated Oct 16, 12:26am ET

Pick status
UCF will play Iowa State in the NCAAF on October 19

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Updated Oct 16, 12:26am ET

  • #10 LSU (5-1) is coming off a 20-10 win against South Carolina.
  • #17 Vanderbilt (5-1) received their first loss of the season with a 14-34 scoreline against Alabama.
  • Last time these two teams met was November 23rd, 2024, with a 24-17 LSU victory.

#17 Vanderbilt hosts the LSU Tigers in an exciting SEC showdown between two teams looks to position themselves towards mid-season. The Tigers, who won their last matchup last year, hold an historic winning record versus the Commodores with a 25-7-1 record. The game will be played at noon at FirstBank Stadium in Nashville, Tennessee.

VANDERBILT COMMODORES vs. LSU TIGERS Overview Watch On: ABC

DATE & TIME

SATURDAY, OCTOBER 18, 2025 @ 12:00 PM ET
VANDERBILT COMMODORES
FirstBank Stadium
Nashville, Tennessee
LSU TIGERS
GAME ODDS
BetOnline
VANDERBILT COMMODORES -2.5 (-105)
LSU TIGERS +2.5 (-105)

LSU Roars for Another Win

LSU is coming off a big win against South Carolina, placing them at a 5-1 record and a #10 ranking in the nation. The Tigers are only permitting 11.8 points from their opponents this season, consolidating them as a defensive focused team, while Vanderbilt is offensive focuses, making this an interesting match.

The Tigers will be led offensively by their QB, Garrett Nussmeier, who has thrown 9 TDs, 5 INTs and a total of 1,411 passing yards. The 5 interceptions so far might be something to worry about, as this can be seen as reckless, so he'll need to bring his A-game while playing the Commodores on the road.

Vanderbilt Focused on Offensive Power

The Commodores just came off a tough battle against Alabama, so they'll be looking to bounce back this week. They'll host their SEC rivals with a chance to get back on winning terms and show why they're a top offense this season.

Quarterback Diego Pavia has really impressed so far with 14 TDs and only 4 INTs so far, he has also scored 2 rushing TDs. The team has shown they have offensive power, which will be a huge test against LSU's defense. Vanderbilt is currently ranked 7th in the nation in points scored with 43.2.

#10 LSU vs #17 Vanderbilt NCAAF Pick

It's set to be a competitive and evenly matched game with a -2.5 spread favoring Vanderbilt. The over/under for the game is 48.5, so expect this to be a tight and high scoring game.

Our prediction for this game is Vanderbilt covering the -2.5 point spread. The home advantage that Vandy will have this game makes us give them the slight edge against LSU. The only loss this season was against a tough Alabama team, so we expect them to bounce back this weekend.

Pick
Vanderbilt -2.5
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