Villanova vs Depaul NCAAB Pick: Wednesday Big East Action (March 4)

Published Mar 4, 6:08am ET by

Demilade Adelekun - Betting Preview Analyst and Sports Writer

Last updated Mar 4, 6:08am ET

Pick status
basketball

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  • Villanova is coming off an 89-57 loss at St. John's on Saturday.
  • DePaul beat Marquette on Sunday to win their third straight road game.
  • The last time these two met, Villanova beat DePaul 71-66 on December 31.

Villanova travels to Chicago to take on DePaul on Wednesday night. The Wildcats are looking to bounce back from a blowout loss.

DePaul Blue Demons vs. Villanova Wildcats Overview Watch On: Peacock

DATE & TIME

Wednesday, March 4, 2026 @ 7:00 PM ET
DePaul Blue Demons
Wintrust Arena
Chicago, IL
Villanova Wildcats
GAME ODDS
BetOnline
DePaul Blue Demons +3.5 (-108)
Villanova Wildcats -3.5 (-112)

Tough Night in MSG

Villanova is 22-7 overall, 13-5 in the Big East, and 3rd in the conference. They firmly secured their place in the big dance, slated around a 5 seed. For More March Madness Betting Odds and Predictions, see the Full Hub".

Villanova has been one of the best teams in the Big East, but did not show up against top-ranked St. John's. This 30-point blowout was one of their worst defeats of the year and brings into question whether they're a legitimate tier below the top two of the conference. This game against DePaul will surely be a statement to prove otherwise.

DePaul's Late Season Push

DePaul is 16-13 overall, 8-10 in the Big East, and 5th in the conference. Though they have made major strides from their previous seasons, they are currently well outside NCAA Tournament consideration.

The Blue Demons are getting hot at the right time. They have won four of their last five games. A big reason is CJ Gunn's play. He is good for nearly 14 a game, and a big game from him can help them upset the Wildcats.

Villanova vs Depaul NCAAB Pick:

Villanova vs DePaul will be an interesting one. DePaul is playing its best basketball of the year, but Villanova is a proven elite team. We think they are still a tier above the rest of the Big East and will show it against DePaul. Our pick is Villanova (-3.5)

Pick
Depaul (-3.5)
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