#21 Louisville vs SMU NCAAB Pick: Midweek ACC Showdown (Feb 17)

Published Feb 16, 7:06pm ET by

Demilade Adelekun - Betting Preview Analyst and Sports Writer

Last updated Feb 16, 7:06pm ET

Pick status
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Updated Feb 16, 7:22pm ET

  • In their last outing, Louisville beat Baylor 82-71 on February 14.
  • SMU lost a close game 79-78 at Syracuse in their last match.
  • When these two met earlier in the season, Louisville defeated SMU 88-74.

Louisville heads to Moody Coliseum off a solid win over Baylor. SMU aims to regroup after a close road loss at Syracuse.

SMU Mustangs. vs. Louisville Cardinals Overview Watch On: ESPN2

DATE & TIME

TUESDAY, FEBRUARY 17, 2026 @ 7:00 PM ET
SMU Mustangs.
MOODY COLISEUM
UNIVERSITY PARK, TEXAS
Louisville Cardinals
GAME ODDS
BetOnline
SMU Mustangs. +2.5 (-110)
Louisville Cardinals -2.5 (-110)

Cardinal's high-octane offense

Louisville is 19-6 overall and 8-4 in the ACC and ranked #21 in the AP Poll. The Cardinals have been scoring in bunches, including 82 points vs Baylor, 118 vs Nc State, and 88 vs Wake Forest.

The guard duo of Ryan Conwell and Mikel Brown Jr have continued to electrify. The two are combining for nearly 37 points and 8 assists a game. Can these two get it done in Texas?

Mustangs Battling to Stay Competitive

SMU is 17-8 overall and 6-6 in ACC play entering this week. They had a good start to conference play, but are currently 2-3 in their last five games. 

SMU is not shy of scoring; they average over 86 points a game. This is greatly due to the guard play of Boopie Miller. He averages nearly 19 points and 7 assists a night. A big game from him can be the trick to knock off Louisville.

#21 Louisville vs SMU NCAAB Pick


Louisville vs SMU is going to come down to defense. Both teams can score in bunches, and whoever can make meaningful stops will win this one. In Louisville's last 5 games, they have kept all of its opponents to below 80 points, while SMU has only been able to do that in two of its last five. We believe Louisville will be able to maintain the firepower of SMU enough to take the points. Our pick is Louisville ATS (-2.5).

Pick
Louisville ATS (-2.5)
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