Spurs vs Sixers NBA Pick: Who Has The Edge In This Interconference Matchup? (Apr 6)

Published Apr 5, 12:13pm ET by

James Tillman - Betting Preview Analyst and Sports Writer

Last updated Apr 5, 12:13pm ET

Pick status
Who has the edge in our Spurs vs Sixers matchup?

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Updated Apr 5, 12:13pm ET

  • The Spurs are 59-16 and sit in the No 2 spot out West.
  • Meanwhile, Philadelphia is 43-35 and ranks seventh in the East.
  • These teams previously met on Mar. 3, with the Spurs winning 131-91.

One of the games on Monday's NBA slate features the San Antonio Spurs hosting the Philadelphia 76ers. Who has the edge in our Spurs vs Sixers pick?

San Antonio Spurs vs. Philadelphia 76ers Overview Watch On: NBCS-PH

DATE & TIME

MONDAY, APRIL 6, 2026 @ 8:00 PM ET
San Antonio Spurs
Forst Bank Center
San Antonio, TX
Philadelphia 76ers
GAME ODDS
BetOnline
San Antonio Spurs -8.5 (-110)
Philadelphia 76ers +8.5 (-110)

Spurs look to regroup after an overtime loss to Denver

San Antonio had won 11 straight going into the weekend. But that streak ended with a 136-134 loss to the Denver Nuggets.

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The Spurs were up 107-96 with 9:08 left to play in regulation. However, Denver outscored San Antonio 40-27 over the remaining 14 minutes (including overtime) while holding the Spurs to 33 percent shooting.

Victor Wembanyama was one of six players in double figures for San Antonio. His final stat line included an impressive 34 points, 18 rebounds, seven assists, and five blocks. Stephon Castle contributed 20 points, nine assists, and five rebounds.

Philadelphia aims for its third win in four games

The Sixers saw their win streak end with a 116-93 loss to the Detroit Pistons on Saturday night.

Philadelphia overcame a double-digit deficit to tie the game in the second quarter. But a 15-4 surge helped the Pistons take an 11-point lead into the break before extending their advantage to 26 points in the second half.

Tyrese Maxey was one of four players in double figures. He scored a team-high 23 points on 8-for-17 shooting from the field. Paul George added 20 points, five rebounds, and four assists.

Spurs vs Sixers NBA Pick

Here's a look at what you need to know for both teams ahead of this contest.

  • The Spurs are 11-1 (SU) in their last 12 games.
  • San Antonio is 6-6 ATS in its previous 12 outings.
  • The Sixers are 8-4 (SU) in their last 12 contests.
  • Philadelphia is 6-3 ATS in its previous nine matchups.

The Spurs are 3-11 in the previous 14 meetings in this series. However, San Antonio is ranked in the top five offensively and is a top-10 defensive squad.

Pick
San Antonio Spurs
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