Sixers vs Cavaliers NBA Pick: Who Has The Edge In This Eastern Conference Matchup? (Jan 14)

Published Jan 13, 7:19pm ET by

James Tillman - Betting Preview Analyst and Sports Writer

Last updated Jan 13, 7:19pm ET

Pick status
The Sixers host the Cavaliers in a Eastern Conference battle on Wednesday night.

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Updated Jan 13, 8:09pm ET

  • The Sixers are 22-16 and rank fifth in the East.
  • Meanwhile, Cleveland is 22-19 after a 123-112 loss to the Utah Jazz.
  • These teams previously squared off on Nov. 5, 2025, with the Cavaliers claiming a 132-121 victory.

One of the games on Wednesday's NBA slate features the Philadelphia 76ers hosting the Cleveland Cavaliers. Who has the edge in our Sixers vs Cavaliers pick?

Philadelphia 76ers vs. Cleveland Cavaliers Overview Watch On: ESPN

DATE & TIME

WEDNESDAY, JANUARY 14, 2026 @ 7:00PM ET
Philadelphia 76ers
Xfinity Mobile Arena
Philadelphia, PA
Cleveland Cavaliers
GAME ODDS
BetOnline
Philadelphia 76ers -3.5 (-110)
Cleveland Cavaliers +3.5 (-110)

Sixers Coming Off A Home-And-Home Split Against Toronto

Philadelphia has won three of its last four games, including a 115-102 victory against the Toronto Raptors.

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The Sixers were up by a huge 80-51 margin at the break, thanks to shooting 27 of 37 from the field and 13-for-20 from downtown. Toronto put together a better effort in the second half, but it wasn't enough to keep the road team from rolling to a double-digit win.

Tyrese Maxey put up a team-high 33 points and collected four rebounds. He converted 10 of his 16 overall attempts and shot 6-of-9 from beyond the arc.

Cleveland Hopes To Regroup Following Loss To Jazz

After a 120-116 win over Indiana, the Cavaliers have dropped two of their last three contests. This includes a 123-112 loss to the Utah Jazz.

Cleveland led by 12 at the break before Utah rallied to pull ahead 90-89 early in the fourth quarter. And thanks to a 16-6 burst that spanned three minutes, the Jazz seized control of the game and held on down the stretch.

Darius Garland was the top performer for the Cavaliers. He scored 23 points, handed out eight assists, and knocked down five of his nine attempts from long range.

Sixers vs Cavaliers NBA Pick

Here's a look at what you need to know for both teams ahead of this contest.

  • The Sixers are 3-2 straight-up (SU) in their last five games.
  • Philadelphia is 3-2 ATS in its previous five outings.
  • The Cavaliers are 2-3 in their last five contests.
  • Cleveland is 1-4 ATS in its previous five matchups.

Philly has lost four of the previous five meetings in this series and is 3-5 against Central Division opponents this season. Simply put, going with Cleveland is the safe bet here.

Pick
Cleveland Cavaliers
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