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Celtics vs Sixers NBA Pick: Divisional Foes Square Off In Boston (Oct 22)

Published Oct 20, 2:07pm ET by

James Tillman - Betting Preview Analyst and Sports Writer

Last updated Oct 20, 2:07pm ET

Pick status
The Celtics look to upend the Sixers when these divisional foes clash on Wednesday night.

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Updated Oct 20, 2:07pm ET

  • The Boston Celtics ended their preseason with a 3-1 mark after a 110-108 victory against the Toronto Raptors.
  • Philadelphia snapped its three-game losing streak to end its exhibition slate with a 126-110 win over the Minnesota Timberwolves.
  • The last regular-season meeting between these teams took place on Mar. 6, with the Celtics winning by a score of 123-105.

One of the games on Wednesday's NBA slate features the Boston Celtics hosting the Philadelphia 76ers. Who has the edge in our Celtics vs Sixers pick?

Boston Celtics vs. Philadelphia 76ers Overview Watch On: NBCS-BOS

DATE & TIME

WEDNESDAY, OCTOBER 22, 2025 @ 7:30 PM ET
Boston Celtics
TD Garden
Boston, MA
Philadelphia 76ers

Xavier Tillman's Clutch Bucket Enables Celtics To Outlast Toronto In Preseason Finale

This contest came down to the last few possessions. With the game tied at 108, Celtics big man Xavier Tillman Sr. hit the game-winning basket with 1.4 seconds left, allowing the Cs to conclude their preseason with a 3-1 mark.

Derrick White led the men in green with 33 points, nine rebounds, six assists, and four blocked shots on 10-for-23 shooting from the floor. Anfernee Simons added 14 points and four rebounds off the bench.

Forward Jayson Tatum could miss the entirety of the 2025-26 campaign. It will be interesting to see if this group can still contend for one of the top spots in the conference without its top scorer in the fold.

Joel Embiid, Sixers End The Preseason With A Win Over The Timberwolves

Philadelphia was 0-3 heading into their preseason finale against Minnesota. But thanks to a solid offensive showing in which the team scored at least 30 points in every quarter, the Sixers concluded their preseason slate with a 126-110 victory.

Tyrese Maxey was one of three starters to reach double figures. He finished with 27 points, seven assists, four rebounds, and two steals. VJ Edgecombe scored 26 points, along with six rebounds, five steals, and three assists.

Joel Embiid, who hadn't played in eight months, registered 14 points, eight assists, seven rebounds, and three steals. In what has been an injury-plagued career, the Sixers are hoping that their talented big man can stay healthy this season.

Injury / Suspension
PLAYER STATUS
Jayson Tatum INJURED
Paul George INJURED

Celtics vs Sixers NBA Pick

Here's a look at a few betting trends for both teams ahead of the season opener.

  • The Celtics are 8-2 straight-up (SU) in their last 10 home games.
  • Boston is 2-4 ATS in its previous six outings.
  • The Sixers are 1-14 in their last 15 contests.
  • Philly has covered the spread just seven times in its previous 20 matchups against the Celtics.

Boston had won four of the last five meetings this series, and the Sixers 2-15 in their previous 17 road contests. With that in mind, the edge goes to the Cs in this matchup.

Pick
Boston Celtics
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