Celtics vs Pacers NBA Pick: Will Boston Hand Indiana Its Fifth Straight Loss? (Dec 22)

Published Dec 21, 4:52pm ET by

James Tillman - Betting Preview Analyst and Sports Writer

Last updated Dec 21, 4:52pm ET

Pick status
The Celtics aim for their third straight victory when they host the Pacers on Monday night.

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Updated Dec 21, 4:52pm ET

  • The Celtics are 17-11 and have the third-best record in the East.
  • Meanwhile, injury-riddled Indiana has the second-worst record in the Eastern Conference at 6-22.
  • These teams previously squared off on Dec. 29, 2024, with the Pacers claiming a 123-114 victory.

One of the games on Monday's NBA slate features the Boston Celtics hosting the Indiana Pacers. Who has the edge in our Celtics vs Pacers pick?

Boston Celtics vs. Indiana Pacers Overview Watch On: FDSIN and NBCS-BOS

DATE & TIME

MONDAY, DECEMBER 22, 2025 @ 7:30PM ET
Boston Celtics
TD Garden
Boston, MA
Indiana Pacers
GAME ODDS
BetOnline
Boston Celtics -8.5 (-116)
Indiana Pacers +8.5 (-114)

Celtics Aiming For Third Straight Win

Following back-to-back losses to the Bucks and Pistons, Boston enters this matchup riding a two-game win streak. This includes a 112-96 victory against the Toronto Raptors.

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Despite blowing a double-digit lead, the Celtics held a three-point edge entering the fourth quarter. And thanks to a 29-16 advantage in the final frame, the short-handed Celtics handed Toronto its seventh loss in 10 outings.

Payton Pritchard led a scoring effort that included six players reaching double figures. He finished with 33 points on 13-for-24 shooting overall and a 4-for-9 effort from beyond the arc. He also handed out 10 assists and snagged seven rebounds.

Indiana Looks To Snap Its Four-Game Losing Skid

After defeating Sacramento 116-105, the Pacers have dropped their last four contests. Their latest setback includes a 128-109 loss to the New Orleans Pelicans.

The Pels raced out to a 44-27 after the opening stanza before Indiana trimmed the deficit to 46-41 in the second quarter. However, New Orleans concluded the first half with an 18-8 burst en route to its fourth consecutive win.

Pascal Siakam scored a team-high 22 points, along with five rebounds and three assists. Johnny Murphy paced the second unit with 18 points, connecting on seven of his 10 shot attempts.

Celtics vs Pacers NBA Pick

Here's a look at what you need to know for both teams ahead of this contest.

  • The Celtics are 7-2 straight-up (SU) in their last nine games.
  • Boston is 5-1 ATS in its previous six home outings.
  • The Pacers are 1-4 in their last five contests.
  • Indiana is 4-1 ATS in its previous five matchups against the Celtics.

The Cs have won seven of the previous 10 meetings in this series and Indiana has dropped 15 of its last 16 road games. Given the trends, the edge goes to Boston.

Pick
Boston Celtics
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