Celtics vs Cavaliers NBA Pick: Can Cleveland Make It Four Straight? (Oct 29)

Published Oct 28, 6:19am ET by

James Tillman - Betting Preview Analyst and Sports Writer

Last updated Oct 28, 6:19am ET

Pick status
The Celtics seek their second straight victory when they host the Cavaliers on Wednesday night.

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Updated Oct 28, 6:19am ET

  • The Boston Celtics improved to 1-3 following a 122-90 victory against the New Orleans Pelicans.
  • Meanwhile, Cleveland is 3-1 after a 116-95 win over the Detroit Pistons.
  • These teams previously squared off on Feb. 28, with the Cavaliers claiming a 123-116 victory.

One of the games on Wednesday's NBA slate features the Boston Celtics hosting the Cleveland Cavaliers. Who has the edge in our Celtics vs Cavaliers pick?

Boston Celtics vs. Cleveland Cavaliers Overview Watch On: ESPN

DATE & TIME

WEDNESDAY, OCTOBER 29, 2025 @ 7:00 PM ET
Boston Celtics
TD Garden
Boston, MA
Cleveland Cavaliers

Celtics Finally Got Their First Win Of The Season

After starting the season with three consecutive losses, Boston finally broke into the win column with a convincing 122-90 victory against the New Orleans Pelicans on Monday night.

The Celtics led 87-78 heading into the final frame. After New Orleans pulled within five points (91-86), Boston finished the game with a 31-4 run on its way to a 32-point win.

Anfernee Simons led the way with 25 points and six rebounds off the bench. Payton Pritchard added 18 points and eight assists, while Jaylen Brown contributed 15 points, seven boards, and four dimes.

Cleveland Aiming For Another Dominant Victory

Following an opening-night loss to New York, the Cavaliers have bounced back with three straight wins, including a 116-95 victory against the Detroit Pistons on Monday.

Cleveland put the game away early, racing out to a 63-41 lead at halftime. The Cavaliers extended their advantage to as many as 25 points in the fourth quarter en route to a dominant victory.

Donovan Mitchell scored a game-high 35 points on 13-for-18 shooting from the floor and a 7-for-8 effort from the charity stripe. Jarrett Allen finished with 20 points, seven rebounds, and two assists.

Injury / Suspension
PLAYER STATUS
Jayson Tatum INJURED
Lonzo Ball INJURED
Darius Garland INJURED

Celtics vs Cavaliers NBA Pick

Here's a look at what you need to know for both teams ahead of this contest.

  • The Celtics are 14-5 straight-up (SU) in their last 19 home games.
  • Boston is 1-4 ATS in its previous five outings.
  • The Cavaliers are 6-2 in their last eight road contests.
  • Cleveland is 5-1 against the spread in its previous six matchups against the Celtics.

Although Boston holds a slight 3-2 edge in the last five meetings in this series, the edge goes to the Cavaliers in this Eastern Conference matchup.

Pick
Cleveland Cavaliers
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