Bulls vs Pistons NBA Pick: Divisional Foes Clash In The Windy City (Oct 22)

Published Oct 20, 10:38pm ET by

James Tillman - Betting Preview Analyst and Sports Writer

Last updated Oct 20, 10:38pm ET

Pick status
The Bulls hope to start the season with a win over the Pistons when these divisional foes clash on Wednesday night.

Shutterstock

  • The Chicago Bulls ended the preseason with a 3-2 mark following a 126-120 win against the Minnesota Timberwolves.
  • Detroit concluded its exhibition slate with a 119-98 victory over the Washington Wizards.
  • The last regular-season meeting between these teams took place on Feb. 12, with the Pistons claiming a 128-110 victory.

One of the games on Wednesday's NBA slate features the Chicago Bulls hosting the Detroit Pistons. Who has the edge in our Bulls vs Pistons pick?

Chicago Bulls vs. Detroit Pistons Overview Watch On: CHSN

DATE & TIME

WEDNESDAY, OCTOBER 22, 2025 @ 8:00 PM ET
Chicago Bulls
United Center
Chicago, IL
Detroit Pistons
GAME ODDS
BetOnline
Chicago Bulls +3.5 (-112)
Detroit Pistons -3.5 (-108)

Matas Buzelis Leads Balanced Attack As Bulls Outlast Timberwolves

Chicago trailed by three points heading into the final frame. But thanks to a 40-point explosion in the fourth quarter, they managed to hold on for 126-120 victory, concluding their preseason with a 3-2 record.

The Bulls' offense placed seven players in double figures. Matas Buzelis led the way with 19 points on 8-for-13 shooting overall and 2-for-5 from deep. Julian Phillips led the bench unit with 17 points and six boards in 22 minutes of action.

Detroit Cruised To An Easy Victory Over Wizards Thanks To Hot Start

The Pistons entered their season finale amid consecutive losses to the Milwaukee Bucks and Cleveland Cavaliers. However, they quickly raced out to an 11-point lead during the game's first 12 minutes.

Washington did get within six points at the break, but the momentum would be short lived. Detroit responded with a 62-47 scoring advantage in the second half on its way to an easy 119-98 victory.

Jalen Duren paced the offense with 20 points, six rebounds, and two steals. Meanwhile, Cade Cunningham scored 16 points and grabbed 12 rebounds, connecting on six of his 10 shot attempts.

Injury / Suspension
PLAYER STATUS
Zach Collins INJURED
Coby White INJURED
Jaden Ivey INJURED

Bulls vs Pistons NBA Pick

Here's a look at a few betting trends for both teams ahead of the season opener.

  • The Bulls are 14-6 straight-up (SU) in their last 20 games.
  • Chicago is 1-7 ATS in its previous eight outings against divisional opponents.
  • The Pistons are 13-7 in their last 20 contests against Eastern Conference teams.
  • Detroit has covered the spread four times in its previous six matchups against the Bulls.

Chicago has dropped the last three meetings in this series. And with Coby White out of the mix for the next two weeks, that trend is expected to continue when these teams clash at the UC on Wednesday night.

Pick
Detroit Pistons
New Player Bonus
50% up to $1000