Bucks vs Wizards NBA Pick: Conference Rivals Clash In Milwaukee (Oct 22)

Published Oct 21, 6:10am ET by

James Tillman - Betting Preview Analyst and Sports Writer

Last updated Oct 21, 6:10am ET

Pick status
The Bucks look to knock of the Wizards when these teams clash on Wednesday night.

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  • The Milwaukee Bucks concluded their preseason with a 3-1 mark following a 116-112 loss to the OKC Thunder.
  • Washington ended its exhibition slate with a 119-98 loss to the Detroit Pistons.
  • The last regular-season meeting between these teams took place on Feb. 21, with the Bucks claiming a 104-101 victory.

One of the games on Wednesday's NBA slate features the Milwaukee Bucks hosting the Washington Wizards. Who has the edge in our Bucks vs Wizards pick?

Milwaukee Bucks vs. Washington Wizards Overview Watch On: FDSWI

DATE & TIME

WEDNESDAY, OCTOBER 22, 2025 @ 8::00 PM ET
Milwaukee Bucks
Fiserv Forum
Milwaukee, WI
Washington Wizards
GAME ODDS
BetOnline
Milwaukee Bucks -8.5 (-115)
Washington Wizards +8.5 (-105)

Bucks End Preseason Slate With First Loss In Four Contests

Milwaukee held a slim 90-87 lead heading into the fourth quarter. But thanks to a 29-22 burst by OKC over the final 12 minutes, the Bucks saw their three-game win streak come to end with a 116-112 loss to the defending champs.

Cole Anthony led the team with 21 points off the bench on 7-for-11 shooting overall and 5-for-6 from beyond the arc. Giannis Antetokounmpo added 16 points, seven rebounds, four assists, and two steals while connecting on five of his eight shot attempts.

Quick Start By Detroit Doomed Washington In Preseason Finale

The Wizards trailed 29-18 after the first quarter and 39-23 midway through the second. Sure, the team battled back to get within six points at the break. But the Pistons responded with a 62-47 scoring advantage in the second half en route to a 21-point victory.

Kyshawn George was one of four players to reach double figures. He led the way with 20 points, six rebounds, and two assists, going 8-of-11 from the field. CJ McCollum finished with 17 points, four rebounds, and two assists. He shot 4-for-7 from long range.

Injury / Suspension
PLAYER STATUS
Gary Harris INJURED
Carlton Carrington INJURED

Bucks vs Wizards NBA Pick

Here's a look at what you need to know for both teams ahead of this contest.

  • The Bucks are 9-4 straight-up (SU) in their last 13 games.
  • Milwaukee is 5-1 ATS in its previous six home outings.
  • The Wizards are 1-8 in their last nine contests against the Bucks.
  • Washington has covered the spread five times in its previous 16 matchups.

In addition to the aforementioned trends, the Bucks have won four of the previous five meetings in this series. With that in mind, the edge goes to the home team in this Eastern Conference matchup.

Pick
Milwaukee Bucks
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