Last updated Nov 20, 4:21am ET

High-quality action in England’s Premier League resumes following the November international break on Saturday. A stacked round of matches is set, including showdowns between Newcastle and Man City, and the first North London derby of the campaign. You can find our Premier League picks for the upcoming weekend here.

Premier League Matchday 12 Schedule

StatInformation
WhenSaturday, November 22, 2025 – Monday, November 24, 2025
WhereVarious Stadiums, England
How to WatchNBC/USA

Premier League Matchday 12 Picks

Burnley vs. Chelsea

The early kick off on Saturday sees Chelsea travel to Burnley. Low-scoring matches following the international break are typically a common angle, and that should be supported based on Burnley’s poor offensive quality this season.

Chelsea bring the better recent form into this clash, and they could move up to second in the standings with a fifth win in six at Turf Moor.

Pick
Chelsea (-201)
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Bournemouth vs. West Ham

Bournemouth’s form has dipped in recent weeks following successive losses against Man City and Aston Villa. Defensively, they were incredibly weak against Villa before the break.

West Ham have improved under Nuno Espirito Santo, winning each of their last two. Their counter-attacking style could make them an interesting play this weekend, as their deep block could cause major issues for the Cherries.

Pick
West Ham (+437)
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Fulham vs. Sunderland

Sunderland’s excellent start to life back in the Premier League has seen them play out draws against Chelsea and Arsenal in recent months. However, questions can still be posed about their away record, as they have created few scoring chances on their travels.

Fulham’s losing run is a glaring concern after losing four of their last five. Therefore, the draw could make plenty of appeal when making Premier League picks this weekend.

Pick
The Draw (+221)
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Wolves vs. Crystal Palace

Winless Wolves will be managed by Rob Edwards for the first time this weekend, and it could be argued that this is a must-win home clash. Crystal Palace have been patchy in the league this season, winning just once across their previous five.

On the road, Palace have been slightly better, winning twice, despite conceding a high xGA of 1.50. A new manager could have no impact, as Palace look a standout chance to beat Wolves for the fourth time in five Premier League meetings.

Pick
Crystal Palace (-102)
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Brighton vs. Brentford

One of the most challenging matches of the weekend to predict could come from the Amex, as inconsistent Brighton host in-form Brentford.

The Bees have won three of their last four, but the Seagulls typically have an ability to throw in an eye-catching performance, which makes them hard to oppose. Draws have been played out in three of the five EPL head-to-head meetings.

Pick
The Draw (+265)
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Liverpool vs. Nottingham Forest

Nottingham Forest will have their sights set on back-to-back wins at Anfield this Saturday.

Liverpool’s damning start to the season continued before the international break, as they were well-beaten by Man City at the Etihad. However, the break could have come at a good time for Arne Slot’s side, and this weekend’s clash could be their perfect opportunity to get back on track.

Pick
Liverpool (-228)
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Newcastle vs. Man City

Man City could move within a point of the Premier League summit this weekend if they are able to claim maximum points at Newcastle. City have won 31 of the last 46 EPL meetings between the sides, and have also won 14 of their last 26 trips to St. James’ Park.

Newcastle’s issues with consistency make them a high-risk selection, meaning that the preference is for the away win when making Premier League picks.

Pick
Man City (+100)
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Leeds vs. Aston Villa

Leeds will be hoping to use Elland Road to their advantage this weekend, as they bid to end a run of four defeats in five. Aston Villa have been consistent over the same period, winning on four occasions.

However, wins for either side in this fixture are rare at Elland Road, with eight of the 15 clashes ending in draws. That could be the eye-catching selection on Sunday.

Pick
The Draw (+228)
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Arsenal vs. Tottenham

The first North London derby of the season is staged on Sunday, as Arsenal bid to contend with a mounting injury list to maintain their advantage at the summit.

The Gunners were defensively vulnerable in their latest draw against Sunderland. However, Tottenham’s 15-year winless record away from home against the Gunners is almost impossible to dismiss. Therefore, a home win looks like the standout selection.

Pick
Arsenal (-242)
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Man United vs. Everton

Monday night’s action in the Premier League is set for Old Trafford, as Man United host Everton.

United have won their last four at the Theatre of Dreams, and they have gone five without defeat in the Premier League. Everton lack a clinical edge in the final third, and their poor head-to-head away record against the Red Devils points to a home victory being a likely outcome.  

Pick
Man United (-131)
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Alex Dudley
Alex Dudley

Sports Analyst and Betting Expert

Alex has over 15 years of experience in sports betting, specializing in soccer and horse racing. He uses his deep knowledge of markets and strategies to guide readers through disciplined and informed betting.

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