Liga MX: Club America vs. Santos Laguna Picks, Odds, and Preview (Oct 4)

It has been a strong start to the 2025 season for Club America, and they could potentially move to the top of the Liga MX standings if they can claim maximum points against Santos Laguna on Saturday.

The hosts come into the weekend in excellent recent form after claiming victories in each of their last two. Meanwhile, they have suffered just one defeat in their opening eleven league matches this season.

Santos Laguna are towards the bottom of the standings after winning just three of their opening eleven matches. Meanwhile, they have lost two of their last three.

Club America vs. Santos Laguna Overview

Odds

Club America vs. Santos Laguna Head-to-Head Record

Club America have won each of their last two against Santos Laguna, which includes a 4-1 success in the previous encounter. Overall, the hosts are unbeaten in their last six against their opponents.

Club America Team News

Minimal changes will be made by the hosts following an excellent 4-1 success against Pumas UNAM last time out. Alejandra Zendejas netted twice in the win last Saturday.

Possible Lineup

Malagon (GK); Alvarez, Caceres, Castillo, Borja; Reyes, Fidalgo; Zendejas, Gutierrez, Saint-Maximum; Zuniga

Santos Laguna Team News

The away team will be without Anthony Lozano on Saturday after the winger was sent off in the 1-0 defeat against Monterrey last time out.

Possible Lineup

Lopez (GK); Amione, Sanchez, Balanta, Abella; Sordo, Mariscal, Guemez, Vargas, Dajome; Ocejo

Club America vs. Santos Laguna Picks

Santos Laguna defended well in their defeat against Monterrey last weekend, meaning that a low-scoring affair should be expected on Saturday. However, the class that Club America boasts at the top of the field should ensure that they land maximum points.