Padres vs Red Sox MLB Odds, Picks, and Predictions (Apr 5)

Published Apr 5, 9:29am ET by

Demilade Adelekun - Betting Preview Analyst and Sports Writer

Last updated Apr 5, 9:29am ET

Pick status
baseball

Updated Apr 5, 9:43am ET

  • San Diego travels to Fenway Park with the series tied 1-1 after splitting the first two games.
  • Walker Buehler starts for the Padres with a 6.75 ERA through one outing.
  • Ranger Suarez takes the mound for Boston, sporting an 8.31 ERA in his Red Sox debut
Boston Red Sox vs. San Diego Padres Overview Watch On: MLB TV

DATE & TIME

Sunday, April 5, 2026 @ 1:35 PM ET
Boston Red Sox
Fenway Park
Boston, MA
San Diego Padres
GAME ODDS
BetOnline
Boston Red Sox -163
San Diego Padres +135

Buehler Searches for Answers After Rocky 2025

Walker Buehler signed with the Padres on a minor league deal in February after a tough 2025 campaign split between Boston and Philadelphia. In his Padres debut on March 30 against San Francisco, Buehler allowed 3 runs on 5 hits over 4 innings in a loss.

As a team, San Diego is hitting just .194 with 3 home runs through eight games. Ramon Laureano leads with 2 homers, 5 RBI and a .308 average. The Padres sit 3-5 overall and 1-1 on the road after splitting the first two games at Fenway (lost 5-2, won 3-2).

Against Suarez, current Padres batters have minimal history. Most face the left-hander for the first time in the American League.

Suarez Stumbles in Red Sox Debut

Ranger Suarez signed a five-year, $130 million deal with Boston in January. It was one of the franchise's biggest pitching investments in history. The 30-year-old Venezuelan left-hander earned it with a stellar 2025 for Philadelphia.

In his Red Sox debut on April 3, Suarez allowed 5 runs on 7 hits over 4.1 innings in Boston's 5-2 win over San Diego. He surrendered 2 home runs, and his 8.31 ERA is the worst mark among qualified AL starters.

Boston is hitting .223 with 8 home runs through eight games. Wilyer Abreu has 3 homers, 6 RBI and a .387 average. The Red Sox sit 2-6 and last in the AL East, five games behind the Yankees.

Against Buehler, current Red Sox batters own limited samples. Most haven't faced him since his brief Boston tenure in 2025.

Padres vs Red Sox Pick

Both pitchers are struggling, but Suarez's 8.31 ERA is worse than Buehler's 6.75. Boston won game one convincingly but the Padres bounced back with a tight 3-2 victory on Friday. Neither team inspires confidence, but when you're getting plus money on the road dog with the pitcher who has the better current ERA, that's value.

Pick: Padres +135

Pick
Padres +135
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