Cardinals vs Tigers MLB Odds, Picks, and Predictions (Apr 4)

Published Apr 3, 4:01am ET by

Demilade Adelekun - Betting Preview Analyst and Sports Writer

Last updated Apr 3, 4:01am ET

Pick status
baseball
  • St. Louis heads to Detroit riding a two-game winning streak.
  • Dustin May makes his second start for the Cardinals.
  • Jack Flaherty gets the ball for the Tigers looking to bounce back from a rough opening start.
Detroit Tigers vs. St. Louis Cardinals Overview Watch On: MLB TV

DATE & TIME

Saturday, April 4, 2026 @ 1:10 PM ET
Detroit Tigers
Comerica Park
Detroit, MI
St. Louis Cardinals
GAME ODDS
BetOnline
Detroit Tigers -175
St. Louis Cardinals +144

May Looking for Rebound After Rough Debut

Dustin May starts for St. Louis after getting hammered in his first outing. He gave up 10 hits allowed over 4 innings with a 13.50 ERA. The 28-year-old signed a one-year, $12.5 million deal with the Cardinals in December after a rough 2025 where he went 8-15 with a 4.96 ERA and 1.42 WHIP in 132.1 innings split between the Dodgers and Red Sox.

St. Louis is hitting .232 with 7 home runs through six games. Nolan Gorman leads with 2 homers and 6 RBI while batting .238. Victor Scott II is hitting .350 to pace the lineup. The Cardinals have scored 29 runs and sit 4-2. The pitching staff ERA is 4.26.

Flaherty Needs to Find His Form After Rocky Start

Jack Flaherty goes for Detroit after allowing 4 hits and 4 walks over 4.1 innings in his first start. The 30-year-old went 8-15 with a 4.64 ERA last year in 161 innings with the Tigers. He struck out 188 but walked 59, and his barrel rate jumped to a career-worst 10.3 percent. Flaherty led the league with 15 losses despite pitching for a playoff team.

Detroit is hitting .215 with just 1 home run through six games. Colt Keith leads at .364 while Dillon Dingler has 5 RBI. The Tigers have scored 24 runs and sit 2-4 after dropping four straight. The pitching staff ERA is 3.78.

Cardinals vs Tigers Pick

Two pitchers coming off terrible first starts will look to bounce back. With that said, Detroit's offense has been dead outside of Keith and Dingler, which helps May. St. Louis has more firepower with Gorman heating up. The Tigers are home, but they're also reeling. We expect May to hold down the fort, and the Cardinals to take the win.

Pick
Cardinals +144
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