#9 TCU vs #1 Duke NCAAB Pick: Horned Frogs Seek Major 2nd Round Upset (Mar 21)

Published Mar 20, 10:21pm ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Mar 20, 10:21pm ET

Pick status

Updated Mar 20, 10:21pm ET

  • TCU survived a thriller against 8-seed Ohio State, winning 66-64 to advance.
  • Duke managed to escape a scare against 16-seed Siena, defeating them 71-65.
  • This will be the very first matchup between these two teams in team history.

TCU and Duke clash in what should be a competitive second round matchup. The Horned Frogs face an uphill battle against top-overall seed Duke, but enter this matchup as one of the hottest teams.

Duke Blue Devils vs. TCU Horned Frogs Overview Watch On: CBS

DATE & TIME

SATURDAY, MARCH 21, 2026 @ 5:15 PM ET
Duke Blue Devils
BON SECOURS WELLNESS ARENA
GREENVILLE, SC
TCU Horned Frogs
GAME ODDS
BetOnline
Duke Blue Devils -800
TCU Horned Frogs +550

TCU Faces an Uphill Battle

TCU survived an exciting 2-point game against Ohio State in the first round, winning the battle of a pair of the tournament's most red-hot teams. Having won ten of their last twelve games, the Horned Frogs will now put their hot streak to the test against top-overall seed Duke. TCU has hung with the best of the Big-12 and has the potential to send Duke home, but they will need absolutely everything going their way for it to happen.

For More March Madness Betting Odds and Predictions, See the Full Hub

Duke Looks for Strong Start

Duke got a scare from Siena in the first half of their 1st-round game. They entered halftime trailing by double digits before eventually working their way back to win by 6 points. It was a concerningly unimpressive win for the team sitting atop the entire field of 68. Against a much more dangerous TCU team, the Blue Devils need to avoid a similar slow start. If they can put the Siena game behind, they should be able to avoid a disaster.

#9 TCU vs #1 Duke NCAAB Pick

TCU and Duke's second round clash has the makings to be a very compelling game. The Horned Frogs are dripping with upset potential and have their eyes on a Duke team that stumbled their way through the first round. On the other hand, the Blue Devils aren't the #1 team in the country for nothing. With their first-round jitters out of the way, they're likely to lock in and return to their typical level of play as they earn the victory.

Pick
Duke Blue Devils (-800)
New Player Bonus
50% up to $1000