New York City vs. Inter Miami MLS Picks: Eastern Conference Rivals Collide (Mar 22)

Published Mar 20, 6:44am ET by

Alex Dudley - Betting Preview Analyst and Sports Writer

Last updated Mar 20, 6:44am ET

Pick status
MLS action is set for Yankee Stadium on March 22. Find the odds and our New York City vs. Inter Miami picks here.

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Updated Mar 20, 6:45am ET

  • New York City FC sit top of the Eastern Conference
  • Inter Miami have won two of their opening four fixtures

Two of the standout teams in the Eastern Conference collide on March 22, as table-topping New York City FC host the reigning MLS Cup champions, Inter Miami.

NYC have made a red-hot start to the new season, winning three of their opening four fixtures. However, this will be their biggest challenge to date when they come up against the reigning MLS Cup champions.

New York City FC vs. Inter Miami Overview Watch On: Apple TV

DATE & TIME

Sunday, March 22, 2026 @ 1:00 PM ET
New York City FC
Yankee Stadium, New York
Inter Miami
GAME ODDS
BetOnline
New York City +124
The Draw +246
Inter Miami +218

NYC Unbeaten in Opening Four Rounds

Pascal Jansen’s New York City FC have made an excellent start to the 2026 season, winning three of their first four fixtures.

They flexed their offensive muscles last weekend, easing to a 3-1 home win over the Colorado Rapids. Nicolas Fernandez scored twice in the success, while Talles Magno rounded off the scoring in the final stages. NYC were efficient in the final third of the field, hitting the target with all five of their shots.

Their counter-attacking style relies heavily on their strong defensive record, with the franchise having allowed an average xGA of just 1.07 per game.

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Possible Lineup
(4-3-3) Freese (GK); Gray, Martins, Trewin, O’Toole; O’Neill, Moralez, Parks; Ojeda, Fernandez, Wolf

Miami Stuttering For Form

The reigning MLS Cup champions have made a slow start to their title defense, reflected by the fact that they have played out draws in each of their last three fixtures in all competitions.

A first setback of the season came in midweek, as Inter were dumped out of the CONCACAF Champions Cup by Nashville. Last weekend, Inter were toothless in the final third of the field, failing to create many scoring opportunities in a 0-0 draw with Charlotte FC.

Lionel Messi will be back in from the start after being rested in that stalemate, with the legendary forward scoring in the midweek loss against Nashville.

Possible Lineup
(4-2-3-1) St. Clair (GK); Mura, Lujan, Micael, Reguilon; De Paul, Bright; Allende, Messi, Segovia; Berterame
NYC vs. Inter Miami Head-to-Head Record
TOTAL NYC Inter Miami DRAWS
Games 15 8 3 4
Goals 46 25 21

New York vs. Inter Miami Picks

It has been a busy week for Inter Miami, and that could be detrimental to their chances this weekend. Therefore, a well-rested NYC could maintain their strong start to the 2026 season.

Pick
New York
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