Published Feb 25, 4:52am ET by
Alex Dudley - Betting Preview Analyst and Sports Writer
Last updated Feb 25, 4:52am ET
Credit: Shutterstock
Updated Feb 25, 4:52am ET
The final clash in the second round of matches in the MLS is set for March 1, as San Diego host St. Louis SC at Snapdragon Stadium. Find our picks here.
San Diego have been red-hot at the start of the new season, scoring nine goals in wins over Pumas UNAM and Montreal in the CONCACAF Champions League and MLS, respectively.
St. Louis avoided defeat in their opening game of the season, but their defensive unit will be tested in California on Sunday.
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|
|---|---|
| San Diego | -155 |
| The Draw | +345 |
| St. Louis | +360 |
Mikey Varas’ San Diego made a host of MLS history in their first campaign in 2025, but their historic push ended early in the playoffs. They will be aiming to go closer to glory in 2026, and the early signs are incredibly promising.
After recording a statement win over Mexican club Pumas UNAM in the Champions League, they dominated from start to finish in their MLS opener against Montreal, eventually recording a 5-0 win.
Christopher McVey, Onni Valakari, and Marcus Ingvartsen all scored in the success, as San Diego showed incredible efficiency, scoring with five of their six shots on target.
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Yoann Damet’s St. Louis will be the huge outsiders in the betting to cause an upset this weekend. Their performances in the MLS have dropped since topping the Western Conference in 2023, finishing a franchise-low 13th in 2025.
Joao Klauss’ departure leaves a huge hole at the top of the field, and they struggled to create many clear chances in their defensive-minded formation in last weekend’s 1-1 draw with Charlotte.
Their game plan this weekend will revolve around them avoiding defeat, but their pace in the wide areas could threaten San Diego on the counter-attack.
| TOTAL | San Diego | St. Louis | DRAWS | |
|---|---|---|---|---|
| Games | 2 | 1 | 0 | 1 |
| Goals | 3 | 2 | 1 |
San Diego’s eye-catching offensive start to the season has seen them score nine goals in three competitive fixtures. This weekend, against a defensive-minded rival with limited attacking quality, they should be capable of recording a second big win in succession.
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Pick
San Diego
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