Orlando vs. Inter Miami MLS Picks: Champions Chasing Immediate Response in Florida Derby (Mar 1)

Published Feb 25, 4:35am ET by

Alex Dudley - Betting Preview Analyst and Sports Writer

Last updated Feb 25, 4:35am ET

Pick status
MLS action is set for Inter&Co Stadium on March 1. Find the odds and our Orlando vs. Inter Miami picks here.

Credit: Shutterstock

Updated Feb 25, 4:35am ET

  • Orlando beaten on MD1 by NY Red Bulls
  • Inter Miami embarrassed on matchday one following heavy loss

Standout action from the MLS is set for March 1, as the first Florida Derby of the 2026 season is slated. Find the odds and our Orlando vs. Inter Miami picks here.

Lionel Messi’s defending MLS Cup champions were humbled on the opening weekend, losing 3-0 against LAFC. A return to form is required on Sunday.

Orlando were also underperformers in the opening round of fixtures, losing 2-1 at home against the NY Red Bulls.

Orlando vs. Inter Miami Overview Watch On: Apple TV

DATE & TIME

Sunday, March 1, 2026 @ 7:00 PM ET
Orlando
Inter&Co Stadium, Orlando
Inter Miami
GAME ODDS
BetOnline
Orlando +188
The Draw +271
Inter Miami +131

Orlando Chasing First Win

Oscar Pareja cut a frustrated figure on opening night in the MLS, as his Orlando City side showed little cutting edge in the final third of a 2-1 loss against the NY Red Bulls.

In fact, winter signing Tiago was the only bright spark from the bench, netting a very late consolation. Martin Ojeda and Duncan McGuire failed to link up the play, and were constantly guilty of losing position.

That could ensure that Ojeda is forced into a wide position this weekend, allowing Brazilian Tiago to play in a central role. 

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Possible Lineup
(4-4-2) Crepeau (GK); Dorsey, Teodoro, Brekalo, Marin; Pasalic, B. Ojeda, Cartagena, M. Ojeda; McGuire, Tiago

Miami Humbled on Opening Night

Once again, a lot will be expected of Inter Miami in 2026, as Lionel Messi bids to guide the franchise to a second straight MLS Cup.

However, the retirements of Sergio Busquets and Jordi Alba were felt on matchday one, as Inter lacked cohesion across the field. Despite dominating the ball, Inter weren’t able to get Messi on the ball in key areas, limiting the champions to just two shots on target.

Tadeo Allende was a shock exclusion in the loss against LAFC, but the winger is expected to return to the starting eleven on Sunday. Gonzalo Lujan is also expected to be recalled in favor of Micael.

Possible Lineup
(4-2-3-1) St. Clair (GK); Fray, Falcon, Lujan, Allen; De Paul, Bright; Allende, Messi, Segovia; Suarez
Orlando vs. Inter Miami Head-to-Head Record
TOTAL Orlando Inter Miami DRAWS
Games 19 7 6 6
Goals 58 28 30

Orlando vs. Inter Miami Picks

Javier Mascherano is expected to go back to basics with Inter Miami this weekend following a heavy loss last weekend. That should suit their chances, while their chances are enhanced based on Orlando’s poor offensive quality shown in their latest defeat.

Pick
Inter Miami
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