#17 Ole Miss vs #3 South Carolina NCAAW Pick: SEC Rivals Clash (Feb 22)

Published Feb 20, 7:14pm ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Feb 20, 7:14pm ET

Pick status
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Updated Feb 20, 8:03pm ET

  • Ole Miss came up short against #7 LSU on Thursday, losing by a score of 78-70 at home.
  • South Carolina dominated Alabama in a 76-57 victory, improving to 26-2 on the season.
  • These two teams last met on February 27, 2025, in a game that South Carolina won 75-59.

Ole Miss and South Carolina face off on Sunday in a key SEC matchup. The Rebels face a major challenge on the road against the Gamecocks. South Carolina enters this game as the heavy favorite.

South Carolina Gamecocks vs. Ole Miss Rebels Overview Watch On: ESPN

DATE & TIME

SUNDAY, FEBRUARY 22, 2026 @ 12:00 PM ET
South Carolina Gamecocks
COLONIAL LIFE ARENA
COLUMBIA, SC
Ole Miss Rebels
GAME ODDS
BetOnline
South Carolina Gamecocks -315
Ole Miss Rebels +285

Ole Miss Eyes Up Major Upset

The Rebels were unable to hold off LSU this week, losing by a single-digit margin. They face an even tougher task on the road this week against #3 South Carolina. In order to avoid dropping their second game in a row, Ole Miss will need leading-scorer and projected top-10 pick Cotie McMahon to continue her dominant play. She is averaging over 25 points per game in the last 8 games, including a 39/10/5 result against Tennessee.

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South Carolina Continues to Dominate

South Carolina's winning streak increased to 7 games this week, as they continue to look like a national champion contender. In their last 3 games they defeated #6 LSU, #19 Tennessee, and #25 Alabama by an average margin of 23 points, with two of those games coming on the road. They return to their home court in Columbia for a fourth ranked matchup in a row against Ole Miss. South Carolina enters as a heavy favorite.

#17 Ole Miss vs #3 South Carolina NCAAW Pick

Ole Miss managed to keep things close with #7 LSU on Thursday, proving they can compete with the SEC's top teams. That being said, South Carolina is a tier above and has been blowing out ranked teams, including a road win over LSU. The Rebels may hang around in the first half, but the Gamecocks will win this one easily.

Pick
South Carolina Gamecocks (-315)
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