Chargers vs Jaguars NFL Pick: An AFC Clash with Wild Card Implications (Nov 16)

Published Nov 13, 10:04pm ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Nov 13, 10:04pm ET

Pick status

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Updated Nov 13, 10:05pm ET

  • The Chargers dominated the Steelers on Sunday night, winning 25-10 to climb to 7-3.
  • Jacksonville collapsed down the stretch against Houston, losing by a score of 36-29.
  • These two teams last met on January 14, 2023, in a game that that the Jaguars won 31-30.

The Chargers and Jaguars meet this week in a clash between playoff hopefuls. Their last meeting was a postseason game that Jacksonville won, but they enter this one as the underdog at home.

Jacksonville Jaguars vs. Los Angeles Chargers Overview Watch On: CBS

DATE & TIME

SUNDAY, NOVEMBER 16, 2025 @ 1:00 PM ET
Jacksonville Jaguars
EVERBANK STADIUM
JACKSONVILLE, FL
Los Angeles Chargers
GAME ODDS
BetOnline
Jacksonville Jaguars +2.5 (-105)
Los Angeles Chargers -2.5 (-105)

Chargers Push for Division Lead

The Chargers continued their impressive season on Sunday, easily dispatching the Steelers to climb to 7-3. They remain a game behind the Broncos in the AFC West, but are steadily pushing for the top spot. The imminent return of rookie RB Omarion Hampton will also provide an eventual boost to the offense, though he is expected to remain out this week. Look for Justin Herbert to have another big game here.

Jaguars Looking to Bounce Back

The Jaguars led the Texans 29-10 in the 4th quarter last week, before collapsing down the stretch. They allowed 26 unanswered points to backup QB Davis Mills, eventually losing and falling to 5-4. Jacksonville has held a Wild Card spot for several weeks now, but is in danger of losing it if they cannot bounce back this week. The health of WR Brian Thomas Jr. will be a crucial factor in their chances of winning this one.

Chargers vs Jaguars NFL Pick:

The Jaguars have beaten some good teams this season and hold the home-field advantage in this game, giving them a chance of winning here. That being said, they have been inconsistent on both sides of the ball. Their collapse last week may drag on into the start of this game, in which case the Chargers will be at a major advantage. Either way, Los Angeles is the more complete team and should win on the road here.

Pick
Los Angeles Chargers -2.5
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