Buccaneers vs Bills NFL Pick: Playoff Hopefuls Seek Bounce Back Win (Nov 16)

Published Nov 11, 7:38pm ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Nov 11, 7:38pm ET

Pick status
Josh Allen

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Updated Nov 11, 7:40pm ET

  • The Buccaneers came up just short against the red-hot Patriots on Sunday, losing 28-23.
  • Buffalo continued to struggle uncharacteristically, falling to the Dolphins in 30-13 defeat.
  • These two teams last faced off back on October 26, 2023, in a game that the Bills won 24-18.

The Buccaneers and Bills meet this week in a battle between likely playoff teams. Despite holding a combined record of 12-6, both teams lost last week and will be looking for a bounce back win.

Buffalo Bills vs. Tampa Bay Buccaneers Overview Watch On: CBS

DATE & TIME

SUNDAY, NOVEMBER 16, 2025 @ 1:00 PM ET
Buffalo Bills
HIGHMARK STADIUM
ORCHARD PARK, NY
Tampa Bay Buccaneers
GAME ODDS
BetOnline
Buffalo Bills -5.5 (-105)
Tampa Bay Buccaneers +5.5 (-105)

Bucs Maintain NFC South Lead

The Buccaneers maintained their 1.5 game lead over the NFC South, despite their loss, thanks to losses by the Panthers and Falcons. The defeat marked their second of the past three weeks for an otherwise very consistent Bucs team. Tampa Bay enters this game in Buffalo seeking a bounce back win to take one step closer to the postseason. They continue to wait for the returns of RB Bucky Irving and WR Chris Godwin.

Bills Approaching Panic Mode

The Bills have been far more inconsistent this season than prior years, made even more clear by their 30-13 loss to Miami following a win against the Chiefs last week. Buffalo is now 2-3 since starting the season 4-0 and continues to fall further behind the Patriots in the AFC East divisional race. Sunday's loss was by far their worst of the season, increasing the need to bounce back this week to regain some momentum.

Buccaneers vs Bills NFL Pick

The Buccaneers and Bills are both on pace to make the postseason, but neither can let up as their recent troubles have open the door for competitors to swoop in. Buffalo already lost their division lead, while Tampa Bay precariously holds onto theirs. The Bills are 4-1 at home which gives them an advantage, but I'd be wary of betting on them to win by 6+. Tampa Bay has been more consistent and should cover here.

Pick
Tampa Bay Buccaneers +5.5
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